This document provides a structured framework for completing risk assessments applicable to laboratory environments handling synthetic research-grade peptide compounds. It is intended as a reference guide and should be adapted to reflect the specific compounds, quantities, and procedures used within each individual laboratory setting.
Regulatory Context
Risk assessments for laboratory chemical handling in the UK are required under the Control of Substances Hazardous to Health Regulations 2002 (COSHH). A written COSHH assessment should be completed before beginning any laboratory work with chemical substances, including research peptides.
Step 1: Hazard Identification
For each compound to be handled, identify the following:
- Physical form (lyophilised powder, solution, small molecule)
- Known or potential toxicological properties (refer to COA and available literature)
- Solvent requirements and associated solvent hazards
- Quantities to be handled
For research peptides with limited toxicological data, apply the precautionary principle — treat as potentially hazardous until data confirms otherwise.
Step 2: Exposure Route Assessment
Identify the likely routes of exposure for each activity:
Inhalation: Risk is highest when handling fine lyophilised powders in open environments
Dermal contact: Risk increases with solvent use (particularly DMSO, which enhances transdermal penetration)
Eye contact: Risk from powder and solution splash during reconstitution and transfer procedures
Ingestion: Low risk in standard laboratory practice; eliminated by no eating, drinking, or cosmetic use in the laboratory
Step 3: Control Measure Hierarchy
Apply control measures in the following order of priority:
Elimination: Can the hazardous substance be avoided entirely? (e.g. substituting a safer solvent)
Substitution: Can a less hazardous alternative be used?
Engineering controls: Use of fume cupboards, laminar flow cabinets, enclosed systems
Administrative controls: Written procedures, training, restricted access, waste management protocols
PPE: Last line of defence — refer to PPE Requirements document for specifications
Step 4: Risk Rating
Rate each identified hazard using a standard likelihood × severity matrix:
LikelihoodSeverityRisk RatingLowLowLow — monitorLowHighMedium — control measures requiredHighLowMedium — control measures requiredHighHighHigh — do not proceed without adequate controls
Step 5: Documentation
A completed COSHH risk assessment should include:
- Substance(s) assessed
- Activity/procedure covered
- Identified hazards and exposure routes
- Control measures in place
- Residual risk rating
- Assessor name and date
- Review date (minimum annual review, or following any incident)
Retain completed risk assessments for the duration of the research programme plus a minimum of 5 years.
