Semax is a synthetic heptapeptide analog derived from the ACTH(4-7) sequence, with an additional C-terminal Pro-Gly-Pro modification engineered to enhance molecular stability relative to the native ACTH fragment.
Molecular Data
Molecular Formula: C₃₇H₅₁N₉O₁₀
Molecular Weight: 813.93 Da
Amino Acid Sequence: Met-Glu-His-Phe-Pro-Gly-Pro (ACTH 4–10 analog with Pro-Gly-Pro C-terminal extension)
Sequence Length: 7 amino acids
Physical Form: White lyophilised powder
Solubility: Soluble in water and bacteriostatic water
Research Context
Semax is referenced in preclinical research examining neuropeptide signalling pathways, BDNF-associated pathway activity, and central nervous system receptor interaction mechanisms. Its structural derivation from ACTH and documented stability profile make it a reliable reference compound for in-vitro CNS signalling research. A substantial body of published literature supports its characterisation across a range of neurological pathway studies.
Laboratory Applications
Used in in-vitro and preclinical research models examining central nervous system neuropeptide signalling, BDNF pathway activity, and ACTH-derived peptide receptor interactions. Standard reference compound for CNS pathway biology research panels.
Storage & Handling
Lyophilised: Store at -20°C, away from light and humidity
Reconstituted: Aliquot and store at -80°C
Recommended solvent: Sterile water
The C-terminal modification enhances stability relative to native ACTH fragments
Avoid repeated freeze-thaw cycles
Purity Standard: ≥99.0% (HPLC verified, batch COA provided)
