MOTS-C is a Mitochondrial-Derived Peptide (MDP) encoded within the mitochondrial 12S rRNA gene, composed of 16 amino acids. It is one of a small class of peptides with mitochondrial genomic origins and is attracting growing research interest as a mitochondrial-nuclear signalling mediator.
Molecular Data
Molecular Formula: C₁₀₁H₁₅₂N₂₈O₃₁S₂
Molecular Weight: 2174.35 Da
Amino Acid Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Sequence Length: 16 amino acids
Physical Form: White lyophilised powder
Solubility: Soluble in water and bacteriostatic water
Research Context
MOTS-C is referenced in preclinical research examining mitochondrial-nuclear retrograde signalling, metabolic pathway regulation, and cellular energy homeostasis mechanisms. As one of the few known peptides encoded within the mitochondrial genome, it represents a distinctive research tool for studying mitochondrial communication pathways in controlled in-vitro experimental models.
Laboratory Applications
Applied in in-vitro research models examining mitochondrial-nuclear signalling dynamics, metabolic regulatory pathway activity, and cellular energy homeostasis mechanisms. Applicable in assays examining the biological roles of mitochondrial-derived peptides.
Storage & Handling
Lyophilised: Store at -20°C
Reconstituted: Aliquot and store at -80°C
Recommended solvent: Sterile or bacteriostatic water
Handle with standard peptide storage protocols to preserve structural integrity
Avoid repeated freeze-thaw cycles post-reconstitution
Purity Standard: ≥99.0% (HPLC verified, batch COA provided)
