GHK-Cu (Glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring copper-binding tripeptide found endogenously in human plasma, saliva, and urine. It is among the most characterised copper-binding peptides available as a laboratory reference standard.
Molecular Data
Molecular Formula: C₁₄H₂₃N₆O₄·Cu
Molecular Weight: 403.91 Da (copper complex); 340.38 Da (free tripeptide)
Amino Acid Sequence: Gly-His-Lys
Sequence Length: 3 amino acids
Physical Form: Blue-green lyophilised powder
Solubility: Soluble in water
Research Context
GHK-Cu has an extensive peer-reviewed in-vitro research history examining collagen biosynthesis signalling pathways, fibroblast activation, and DNA repair mechanisms. Its endogenous origins, copper-chelating properties, and well-characterised molecular profile make it a reliable and widely used reference compound in regenerative biology and longevity research programmes.
Laboratory Applications
Applied in in-vitro research models examining collagen synthesis signalling, fibroblast pathway activity, cellular matrix biology, and longevity-related pathway interactions. Commonly used in dermal biology and cellular senescence research panels.
Storage & Handling
Lyophilised: Store at -20°C, away from moisture and direct light
Reconstituted: Use freshly prepared solutions where possible; store aliquots at -80°C
Recommended solvent: Sterile water
The copper-peptide complex is sensitive to oxidation — minimise air exposure after reconstitution
Purity Standard: ≥98.9% (HPLC verified, batch COA provided)
